Dr. Courtney Lappas
Associate Professor of Biology
Academic Areas of Expertise:
- Molecular Biology
Courses Taught at LVC
Drugs and Society
My research is focused on the use of natural and synthetic immunomodulatory compounds to regulate T lymphocyte activity.
Lappas, N. T. and Lappas, C. M. Forensic Toxicology: Principles and Concepts, second edition, Elsevier, Academic Press, in preparation.
Meier, B. P., Osorio, E.* and Lappas, C. M. A behavioral confirmation and reduction of the natural versus synthetic drug bias, Medical Decision Making, in press.
Meier, B. P. and Lappas, C. M. The influence of safety, efficacy and medical condition severity on natural versus synthetic drug preference, Medical Decision Making, 36: 1011-1019 (2016).
Lappas, N. T. and Lappas, C. M. Forensic Toxicology: Principles and Concepts, Elsevier, Academic Press, 2016.
Lappas, C. M. The immunomodulatory effects of titanium dioxide and silver nanoparticles, Food and Chemical Toxicology, 85: 78-83 (2015).
Lappas, C. M. The plant hormone zeatin riboside inhibits T lymphocyte activity via adenosine A2A receptor activation, Cellular and Molecular Immunology, 12: 107-112 (2015).
Lappas, C. M. “The immunotoxicology of nanomaterials” in the Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology. Edited by Saura Sahu and Daniel Casciano, Wiley (2014).
Weilnau, J. N.*, Black, S. E.*, Chehata, V. J.*, Schmidt, M. P.*, Holt, K. L.*, Carl, L. M.*, Straka, C. J.*, Marsh, A. L., Patton, W. A. and Lappas, C. M. ZnS nanocrystal cytotoxicity is influenced by capping agent chemical structure and duration of time in suspension. Journal of Applied Toxicology, 33(3): 227-237 (2013).
Lappas, C. M. The effect of CGS21680 treatment on thioglycollate-induced peritonitis: An introduction to immunopharmacology. Bioscene. 38: 3-9 (2012).
Lappas, C. M. and Lappas, N. T. d-limonene modulates T lymphocyte activity and viability. Cellular Immunology. 279: 30-41 (2012).
Lappas, C. M. “Allogenic hematopoietic stem cell transplantation followed by graft-versus-host disease: Role of adenosine A2A receptor” in Stem Cells and Cancer Stem Cells: Therapeutic Applications in Disease and Injury. Edited by Eric Hayat, Springer Company, (2011).
Chehata, V. J.*, Domeier, P.D.*, Weilnau, J. N.*, and Lappas, C. M. Adenosine A2A receptor activation limits chronic granulomatous disease-induced hyperinflammation. Cellular Immunology. 267: 39-49 (2011).
Lappas, C. M., Liu, P. C., Linden, J., Kang, E. M., and Malech, H. L. Adenosine A2A receptor activation limits graft-versus-host disease after allogenic hematopoietic stem cell transplantation. Journal of Leukocyte Biology. 87(2): 345-354 (2010).
Srinivasan, S., Bolick, D. T., Lukashev, D., Lappas, C. M., Sitkovsky, M., Lynch, K. R. and Hedrick, C. C. Sphingosine-1-phosphate reduces CD4+ T lymphocyte activation in type-1 diabetes through regulation of hypoxia-inducible factor short isoform I.1 and CD69. Diabetes. 57(2): 484-493 (2008).
Dyer, K.D., Czapiga, M., Foster, B., Foster, P. S., Kang, E. M., Lappas, C. M., Moser, J. M., Naumann, N., Percopo, C. M., Siegel, S. J., Swartz, J. M., De Ravin, S., Rosenberg, H. F. The dblGATA enhancer in the promoter of the GATA-1 gene is not essential for eosinophil differentiation ex vivo. Journal of Immunology. 179(3): 1693-1699 (2007).
Lappas, C. M., Day, Y. J., Marshall, M. A., Engelhard, V. and Linden, J. Adenosine A2A receptor activation reduces hepatic ischemia-reperfusion injury by inhibiting CD1d-dependent NKT cell activation. Journal of Experimental Medicine. 203(12): 2639-2648 (2006).
Naganuma, M., Wiznerowicz, E. B., Lappas, C. M., Linden, J., Worthington, M. T., Ernst, P. B. Critical role for A2A adenosine receptors in the T cell-mediated regulation of colitis. Journal of Immunology. 177(5): 2765-2769 (2006).
Lappas, C. M. and Linden, J. “A2A adenosine receptors and ischemia reperfusion injury” in Adenosine Receptors: Therapeutic Aspects for Inflammatory and Immune Diseases. Edited by Gyorgy Hasko, Bruce Cronstein, Csaba Szabo, CRC Press, (2006).