Connective Tissue Diseases often present clinical challenges due to their chronic nature and developmental changes from birth through adolescence. This course will interweave lab and lecture components to provide a background, history and clinical tools to evaluate and treat four common pediatric connective tissue disorders: Marfan, Ehlers-Danlos, Benign Joint Hypermobility Syndromes, and Williams Syndrome. A thorough approach to examination will be provided including caregiver interview, patient history, full systems review, and physical exam. An orthopedic focused lower quarter assessment will be presented. This comprehensive assessment is applicable to multiple pediatric conditions with lower extremity involvement and will be a cornerstone of the day’s activity. Intervention strategies including therapeutic exercise, neuromuscular (re)education, joint preservation techniques, orthotic and orthoses prescription, home exercise and recreational activity participation will be reviewed. Laboratory sections will provide opportunity for immediate practice of hypermobility screening and special tests, the complete static and dynamic lower quarter assessment and select intervention strategies.