Dr. Erica L. Unger

PEER-REVIEWED PUBLICATIONS

  1. E.L. Unger, C.J. Earley, L. Thomsen, B.C. Jones, R.P. Allen (2013) Effects of IV iron isomaltoside treatment on brain and peripheral iron status in an iron-deficient animal model of restless legs syndrome (RLS). Neuroscience, 246: 179-185.
  2. L.C. Jellen, L. Lu, X. Wang, E.L. Unger, C.J. Earley, R.P. Allen, R.W. Williams, B.C. Jones (2013) Iron deficiency alters expression of dopamine-related genes in the ventral midbrain in mice. Neuroscience, Epub.
  3. B.C. Jones, D.B. Miller, J.P. O’Callaghan, L. Lu, E.L. Unger, G. Alam, R.W. Williams (2013) Systems analysis of genetic variation in MPTP neurotoxicity in mice. NeuroToxicology, 37: 26-34.
  4. W. Nandar, E.B. Neely, E. Unger, J.R. Connor (2013) A mutation in the HFE gene is associated with altered brain iron profiles and increased oxidative stress in mice Biochim Biophys Acta: Molecular Basis of Disease, 1832(6): 729-741. 
  5. R. Rao, I. Tkac, E.L. Unger, K. Ennis, A.R. Hurst, T. Schallert, J.R. Connor, B. Felt, M.K. Georgieff (2013) The iron supplementation dose for perinatal iron deficiency differentially alters the neurochemistry of frontal cortex and hippocampus in adult rats. Pediatric Research, 73(1): 31-37.
  6. E.L. Unger, A.R. Hurst, M.K. Georgieff, T. Schallert, R. Rao, J.R. Connor, N. Kaciroti, B. Lozoff, B. Felt (2012) Behavior and monoamine deficits in pre/perinatal iron deficiency are not corrected by early postnatal moderate or high iron diet in the rat. Journal of Nutrition, 142(11): 2040-2049. 
  7. R.K. Babbs, E.L. Unger, R.L. Corwin (2013) 2-hydroxyestradiol enhances binge onset in female rats and reduces prefrontal cortical dopamine in male rats. Hormones and Behavior, 63(1): 88-96.
  8. M.P. DeAndrade, R. Johnson, E.L. Unger, T. van Groen, K.L. Gamble, Y. Li (2012) Hyperactivity, sleep disturbances, thermal sensory alterations, and elevated serum iron levels in Btbd9 mutant mice. Human Molecular Genetics, 21(18): 3984-3992.
  9. L. Yin, E.L. Unger, L.C. Jellen, C.J. Earley, R.P. Allen, A. Tomaszewicz, B.C. Jones (2012) Systems genetic analysis of multivariate response to iron deficiency in mice. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 302(11): R1282-1296.
  10. L.C. Jellen, E.L. Unger, L. Lu, R.W. Williams, S. Rousseau, X. Wang, C.J. Early, M. Miles, B.C. Jones (2012) Iron regulation in mouse brain involves genes related to dopamine and glutamate. Neurogenetics, 13(2): 147-157.
  11. M.S. Golub, C.E. Hogrefe, E.L. Unger (2012) Social behavior of rhesus monkey infants as influenced by prenatal iron deficiency and MAOA genotype. Genes, Brain and Behavior, 11(3): 278-290.
  12. S. Texel, S. Camandola, B. Ladenheim, S. Rothman, M. Mughal, E. Unger, J. Cadet, M. Mattson (2011) Ceruloplasmin deficiency results in an anxiety phenotype involving deficits in hippocampal iron, serotonin and BDNF. Journal of Neurochemistry, 120(1): 125-134.
  13. S.J. Texel, J. Zhang, S. Camandola, M.R. Mughal, E.L. Unger, D.D. Taub, R.C. Koehler, Z. L. Harris, M.P. Mattson (2011) Ceruloplasmin Deficiency Results in Reduced Levels of Iron and BDNF in the Cerebral Cortex and Striatum, Associated with Increased Vulnerability to Focal Ischemic Stroke. PLoS One, 6(9): e25077.
  14. J.N. Gibson, L.C. Jellen, E.L. Unger, G. Morahan, M. Mehta, C.J. Early, R.P. Allen, L. Lu, B.C. Jones (2011) Genetic analysis of iron deficiency effects on the mouse spleen. Mammalian Genome, 22(9-10): 556-562.
  15. L. Yin, E.L. Unger, L. Lu, E. Richfield, B.C. Jones (2011) Genetic-Based, Differential Susceptibility to Paraquat Neurotoxicity in Mice. Neurotoxicology and Teratology, 33(3): 415-421.
  16. N.V. Hegde, E.L. Unger, G.L. Jensen, P. Hankey, R. Paulson (2011) Interrelationships between tissue iron status and erythropoiesis during postweaning development following neonatal iron deficiency in rats. American Journal of Physiology – Gastrointestinal and Liver Physiology, 300(3): 470-476.
  17. N.V. Hegde, G.L. Jensen, E.L. Unger (2011) A postweaning iron adequate diet following neonatal iron deficiency affects iron homeostasis and growth in young rats. Journal of Nutrition, 141(3): 386-390.
  18. N.V. Hegde, G.L. Jensen, E.L. Unger (2011) Iron chelation down-regulates dopamine transporter expression by decreasing mRNA stability and increasing endocytosis in N2a cells. Experimental Cell Research, 317(4): 405-412.
  19. W.M.Y. Mohamed, E.L. Unger, S.K. Kambhampati, B.C. Jones (2011) Methylphenidate improves cognitive deficits produced by infantile iron deficiency. Behavioral Brain Research, 216(1): 146-152.
  20. E.S. Carlson, S.J. Fretham, E. Unger, M. O’Connor, A. Petryk, T. Schallert, R. Rao, I. Tkac, M. Georgieff (2010) Hippocampus specific iron deficiency alters competition and cooperation between developing memory systems. Journal of Neurodevelopmental Disorders, 2(3): 133-143.
  21. E.L. Unger, C.J. Earley, J.L. Beard (2009) Diurnal cycle influences peripheral and brain iron levels in mice. Journal of Applied Physiology, 106(1): 187-193.
  22. L.E. Bianco, E.L. Unger, C.J. Earley, J.L. Beard (2009) Iron deficiency alters the day-night variation in monoamine levels in mice. Chronobiology International, 26(3): 447-463.
  23. E.L. Unger, J.A. Wiesinger, L. Hao, J.L. Beard (2008) Dopamine D2 receptor expression is altered by changes in cellular iron levels in PC12 cells and rat brain tissue. Journal of Nutrition, 138(12): 2487-2494.
  24. E. L. Unger, T. Paul, L.E. Murray-Kolb, B. Felt, B.C. Jones, J.L. Beard (2007) Early iron deficiency alters sensorimotor development and brain monoamines in rats. Journal of Nutrition, 137(1): 118-124.
  25. J.A. Wiesinger, J.P. Buwen, C.J. Cifelli, E.L. Unger, B.C. Jones, J.L. Beard (2007) Down-regulation of dopamine transporter by iron chelation in vitro is mediated by altered trafficking, not synthesis. Journal of Neurochemistry, 100(1): 167-179.
  26. J.L. Beard, E.L. Unger, L.E. Bianco, T. Paul, S.E. Rundle, B.C. Jones (2007) Early post-natal iron repletion overcomes lasting effects of gestational iron deficiency in rats. Journal of Nutrition, 137(5):1176-1182.
  27. E.L. Unger, J.L. Beard, B.C. Jones (2007) Iron regulation in C57BL/6 and DBA/2 mice subjected in iron overload. Nutritional Neuroscience, 10(1-2): 89-95.
  28. B.C. Jones, J.L. Beard, J.N. Gibson, E.L. Unger, R.P. Allen, K.A. McCarthy, C.J. Earley (2007) Systems genetic analysis of peripheral iron parameters in the mouse. American Journal of Physiology – Regulatory, Integrative and Comparative Physiology, 293(1): R116-124.
  29. E.L. Unger, L.E. Bianco, M.S. Burhans, B.C. Jones, J.L. Beard (2006) Acoustic startle response is disrupted in iron deficient rats. Pharmacology, Biochemistry and Behavior, 84(2):378-384.
  30. E.L. Unger, D.J. Eve, X.A. Perez, D.K. Reichenbach, Y. Xu, M.K. Lee, A.M. Andrews (2006) Locomotor hyperactivity and alterations in dopamine neurotransmission are associated with overexpression of A53T mutant human alpha-synuclein in mice. Neurobiology of Disease, 21(2): 431-443.
  31. A.L. Numis, E.L. Unger, D.L. Sheridan, A.C. Chisnell, A.M. Andrews (2004) The role of membrane and vesicular monoamine transporters in the neurotoxic effects of 1-methyl-4-(2’-aminophenyl)-1,2,3,6-tetrahydropyridine (2’-NH2-MPTP). Molecular Pharmacology, 66(3): 718-727.
  32. E.L. Unger, P. Mazzola-Pomietto, D.L. Murphy, A.M. Andrews (2002) 2’-NH2-MPTP depletes serotonin and norepinephrine in rats: A comparison with 2’-CH3-MPTP. Journal of Pharmacology and Experimental Therapeutics, 303 (2): 527-533.
BOOK CHAPTERS

  1. E.L. Unger, N. Hegde, J.R. Connor. Changes in Brain Gene Expression in Nutrient Deficiencies: an example with iron. In: Preedy V.R., Ross-Watson R., and Martin C.R. (Eds.) The International Handbook of Behavior, Food, and Nutrition. Springer. Springer Press, 2011.
  2. L.E. Bianco, E.L. Unger, J.L. Beard. Iron deficiency and neuropharmacology. In: Yehuda S. & Mostofsky D. (Eds.) Iron deficiency and Overload: From Basic Biology to Clinical Medicine. Humana Press, 2009.