Dr. Courtney Lappas

PUBLICATIONS

1. Lappas, C. M. “Allogenic hematopoietic stem cell transplantation followed by graft-versus-host disease: Role of adenosine A_2A receptor” in Stem cells and cancer stem cells: Therapeutic Applications in Disease and Injury. Edited by Eric Hayat, Springer Company (2011). 
2. Chehata, V. J.*, Domeier, P.D.*, Weilnau, J. N.*, and Lappas, C. M. Adenosine A_2A receptor activation limits chronic granulomatous disease-induced hyperinflammation, Cellular Immunology. 267: 39-49 (2011).     *undergraduate co-author
3. Lappas, C. M., Liu, P. C., Linden, J., Kang, E. M., and Malech, H. L. Adenosine A_2A receptor activation limits graft-versus-host disease after allogenic hematopoietic stem cell transplantation.  Journal of Leukocyte Biology. 87(2): 345-354 (2010).
4. Srinivasan, S., Bolick, D. T., Lukashev, D., Lappas, C. M., Sitkovsky, M., Lynch, K. R. and Hedrick, C. C. Sphingosine-1-phosphate reduces CD4⁺ T lymphocyte activation in type-1 diabetes through regulation of hypoxia-inducible factor short isoform I.1 and CD69.  Diabetes. 57(2): 484-493 (2008).
5. Dyer, K.D., Czapiga, M., Foster, B., Foster, P. S., Kang, E. M., Lappas, C. M., Moser, J. M., Naumann, N., Percopo, C. M., Siegel, S. J., Swartz, J. M., De Ravin, S., Rosenberg, H. F. The dblGATA enhancer in the promoter of the GATA-1 gene is not essential for eosinophil differentiation ex vivo. Journal of Immunology. 179(3): 1693-1699 (2007).
6. Lappas, C. M., Day, Y. J., Marshall, M. A., Engelhard, V. and Linden, J. Adenosine A_2A receptor activation reduces hepatic ischemia-reperfusion injury by inhibiting CD1d-dependent NKT cell activation.  Journal of Experimental Medicine. 203(12): 2639-2648 (2006).
7. Naganuma, M., Wiznerowicz, E. B., Lappas, C. M., Linden, J., Worthington, M. T., Ernst, P. B. Critical role for A_2A adenosine receptors in the T cell-mediated regulation of colitis.  Journal of Immunology.  177(5): 2765-2769 (2006).
8. Lappas, C. M. and Linden, J. “A_2A adenosine receptors and ischemia reperfusion injury” in Adenosine Receptors: Therapeutic Aspects for Inflammatory and Immune Diseases.  Edited by Gyorgy Hasko, Bruce Cronstein, Csaba Szabo, CRC Press, (2006). 
9. Lappas, C. M., Sullivan, G. W. and Linden, J. Adenosine A_2A agonists in development for the treatment of inflammation. Expert Opinion on Investigational Drugs.  14 (7): 797-806 (2005).
10. Lappas, C.M., Rieger, J.M., Linden, J.  A_2A adenosine receptor induction inhibits interferon y production in murine CD4⁺ T cells.  Journal of Immunology.  174 (2): 1073-1080 (2005).
11. Sullivan G.W., Lee D.D., Ross W.G., DiVietro J.A., Lappas C.M., Lawrence M.B., Linden J.  Activation of A_2A adenosine receptors inhibits expression of a4b1 integrin (very late antigen-4) on stimulated human neutrophils.  Journal of Leukocyte Biology.  75 (1): 127-134 (2004). 
12. Goodner, B, Hinkle, G, Gattung, S, Miller, N, Blanchard, M, Qurollo, B, Goldman, BS, Cao, Y, Askenazi, M, Halling, C, Mullin, L, Houmiel, K, Gordon, J, Vaudin, M, Iartchouk, O, Epp, A, Liu, F, Wollam, C, Allinger, M, Doughty, D, Scott, C, Lappas, C, Markelz, B, Flannagan, C, Crowell, C, Gurson, J, Lomo, C, Sear, C, Strub, G, Cielo, C, Slater, S.  Genome sequence of the plant pathogen and biotechnology agent Agrobacterium tumefaciens C58.  Science.  294 (5550): 2323-2328 (2001).

PRESENTATIONS

1. Lappas, C. M., Domeier, P. D.*, and Chehata, V. J.* Adenosine A_2A receptor activation inhibits T cell activity in a murine model of chronic granulomatous disease, presented at the 97^th Annual Meeting of the American Association of Immunologists, Baltimore, MD, May 7-11, 2010.     *undergraduate co-author
2. Schmidt, M. P.*, Chehata, V. J.*, Domeier, P. D.*, Lappas, C. M., and Marsh, A. L. Use of biocompatible zinc sulfide nanocrystals in phototherapeutic applications, presented at the 239^th American Chemical Society Meeting, San Francisco, CA, March 21-25, 2010.     *undergraduate co-author
3. Lappas, C. M., Choi, U. Moayeri, M., Kang, E. M., Malech, H. L., and DeRavin, S. S. In vivo bioluminescent imaging studies following in vivo gene therapy, presented at the 11^th Annual Meeting of the American Society of Gene Therapy, Boston, MA, May 28-June 1, 2008.
4. Naganuma, M., Wiznerowicz, E. B., Lappas, C. M., Linden, J., Ernst, P. B. Stimulation of adenosine A_2A receptors attenuates T cell cytokine responses and favors the development of regulatory T cells that prevent colitis, presented at the AGA Digestive Diseases Week, Chicago, IL, May 14-19, 2005. 
5. Lappas, C. M. and Linden, J. A_2A adenosine receptor induction limits interferon-g production in murine CD4⁺ T cells, presented at the 4^th International Symposium of nucleosides and nucleotides, Chapel Hill, NC, June 6-9, 2004. 
6. Day, Y. J., Yuang, A., Lappas, C. M., French, B., Huang, L., Okusa, M., Linden, J. Activation of A_2A adenosine receptors on CD4⁺ T cells inhibits ischemia-reperfusion injury in liver and heart, presented at the 4^th International Symposium of nucleosides and nucleotides, Chapel Hill, NC, June 6-9, 2004.
7. Lappas, C. M., Rieger, J., Baraldi, P., Linden, J. A_2A adenosine receptor activation inhibits T cell receptor-mediated interferon-gamma production in murine CD4⁺ T cells, presented at the Society for Leukocyte Biology 36^th Annual Meeting, Philadelphia, PA, October 2-5, 2003.
8. Sullivan, G. W., Lee, D. D., DiVietro, J. A., Lappas, C. M., Lawrence, M. B., Linden, J. The activation of A_2A adenosine receptors (A_2AAR) on human neutrophils (PMN) inhibits alpha-4 integrin expression and function as a consequence of cyclic AMP-dependent protein kinase A activity, presented at the 3^rd Annual Colloquium on the Biomechanics of Adhesion Molecules, Charlottesville, VA, July 12-13, 2002.
9. Sullivan, G. W., Lee, D. D., DiVietro, J. A., Lappas, C. M., Lawrence, M. B., Linden, J. The activation of A_2A adenosine receptors (A_2AAR) on human neutrophils (PMN) inhibits alpha-4 integrin expression and function as a consequence of cyclic AMP-dependent protein kinase A activity, presented at FASEB Experimental Biology, New Orleans, April 20-24, 2002.
10. Doughty, D., Lomo, C., Gurson, J., Strub, G., Lappas, C. M., Sear, C., Markelz, B., Flanagan, M. C., Crowell, C., Slater, S., Goodner, B. The fun part: testing hypotheses generated by the complete genomic sequence of A. tumefaciens strain C58, presented at the 21st Annual Crown Gall Meeting, 2000.
11. Lappas, C. M., Gurson, J., Doughty, D., Goodner, B. Role of polyketide compounds in the interaction between Agrobacterium tumefaciens and other organisms, presented at the 20^th Annual Crown Gall Meeting, Dallas, Texas, November 5-7, 1999.
12. Lappas, C. M., Hunkeler, M., Goldsborough, M. The utility of the FTA gene guard system for the analysis of buccal swab transfers, presented at the 10^th International Symposium on Human Identification, Lake Buena Vista, FL, September 29-October 2, 1999.
13. Lappas, C. M., and Goodner, B. The Agrobacterium genome project, presented at the University of Richmond undergraduate research symposium, April 16, 1999.
14. Goodner, B., Markelz, B., Flanagan, M. C., Crowell, C., Racette, J., Schilling, B., Mellors, J., Lappas, C. M., An Agrobacterium genome project at a primarily undergraduate institution—current progress and future goals, presented at the Microbial Genomes III Conference, Chantilly, VA, January 29-February 1, 1999.